Extended analyses support the association of a functional (GT)n polymorphism in the GRIN2A promoter with Japanese schizophrenia

@article{IwayamaShigeno2005ExtendedAS,
  title={Extended analyses support the association of a functional (GT)n polymorphism in the GRIN2A promoter with Japanese schizophrenia},
  author={Yoshimi Iwayama-Shigeno and Kazuo Yamada and Masanari Itokawa and Tomoko Toyota and Takeo Yoshikawa},
  journal={Neuroscience Letters},
  year={2005},
  volume={378},
  pages={102-105}
}
Dysfunction of the N-methyl-D-aspartate (NMDA) type glutamate receptor has been proposed as a mechanism in the etiology of schizophrenia. Recently, we identified a variable (GT)n repeat in the promoter region of the NMDA NR2A subunit gene (GRIN2A), and showed its association with schizophrenia in a case-control study, together with a correlation between the length of the repeat and severity of chronic outcome. In this study, we extended our analyses, by increasing the number of case-control… CONTINUE READING

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