Extended Longevity in Mice Lacking the Insulin Receptor in Adipose Tissue

@article{Blher2003ExtendedLI,
  title={Extended Longevity in Mice Lacking the Insulin Receptor in Adipose Tissue},
  author={M. Bl{\"u}her and B. Kahn and C. Kahn},
  journal={Science},
  year={2003},
  volume={299},
  pages={572 - 574}
}
Caloric restriction has been shown to increase longevity in organisms ranging from yeast to mammals. In some organisms, this has been associated with a decreased fat mass and alterations in insulin/insulin-like growth factor 1 (IGF-1) pathways. To further explore these associations with enhanced longevity, we studied mice with a fat-specific insulin receptor knockout (FIRKO). These animals have reduced fat mass and are protected against age-related obesity and its subsequent metabolic… Expand
1,208 Citations
Extended longevity and insulin signaling in adipose tissue
  • 82
  • PDF
Fat Tissue and Long Life
  • 10
Fat tissue and long life.
  • 24
New insights into cardiac aging.
  • 2
Targeted disruption of growth hormone receptor interferes with the beneficial actions of calorie restriction
  • 282
  • PDF
Deficiency of the lipid synthesis enzyme, DGAT1, extends longevity in mice
  • 30
  • PDF
Insulin, food restriction and the extension of lifespan: the mechanism of longevity.
  • 4
  • PDF
Extended lifespan and reduced adiposity in mice lacking the FAT10 gene
  • 43
  • PDF
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 31 REFERENCES
Effects of food restriction on aging: separation of food intake and adiposity.
  • 182
  • PDF
Genetic differences in effects of food restriction on aging in mice.
  • 126
Action of food restriction in delaying the aging process.
  • E. Masoro, B. Yu, H. Bertrand
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1982
  • 239
  • PDF
Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production
  • 692
  • PDF
Caloric restriction and aging: an update
  • E. Masoro
  • Biology, Medicine
  • Experimental Gerontology
  • 2000
  • 582
  • PDF
Early neonatal death in mice homozygous for a null allele of the insulin receptor gene
  • 549
...
1
2
3
4
...