Extended IL10 haplotypes and their association with HIV progression to AIDS

@article{Oleksyk2009ExtendedIH,
  title={Extended IL10 haplotypes and their association with HIV progression to AIDS},
  author={Taras K Oleksyk and Sadeep Shrestha and Ann L Truelove and James Jerome Goedert and Sharyne M. Donfield and John W Phair and Sameet Mehta and Stephen J. O'Brien and Mike W. Smith},
  journal={Genes and Immunity},
  year={2009},
  volume={10},
  pages={309-322}
}
Interleukin-10 (IL-10) is a pleiotropic cytokine with both immunosuppressive and immunostimulatory functions. Its roles in infections and autoimmunity may have resulted in selective pressures on polymorphisms within the gene, leading to genomic coexistence of several semi-conserved haplotypes involved with diverse pathogen interactions during genomic evolution. Previous studies focused either exclusively on promoter haplotypes or on individual SNPs. We genotyped 21 single nucleotide… CONTINUE READING