Extended‐Spectrum β‐Lactamases: Epidemiology, Detection, and Treatment

@article{Nathisuwan2001ExtendedSpectrumE,
  title={Extended‐Spectrum $\beta$‐Lactamases: Epidemiology, Detection, and Treatment},
  author={Surakit Nathisuwan and David S. Burgess and James S. Lewis},
  journal={Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy},
  year={2001},
  volume={21}
}
Extended‐spectrum β‐lactamases (ESBLs) are extremely broad spectrum β‐lactamase enzymes found in a variety of Enterobacteriaceae. Most strains producing these β‐lactamases are Klebsiella pneumoniae, other Klebsiella species (i.e., K. oxytoca), and Escherichia coli. When producing these enzymes, organisms become highly effective at inactivating various β‐lactam antibiotics. In addition, ESBL‐producing bacteria are frequently resistant to many classes of antibiotics, resulting in difficult‐to… 
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Global dissemination of β2-lactamases mediating resistance to cephalosporins and carbapenems
  • T. Gootz
  • Biology
    Expert review of anti-infective therapy
  • 2004
TLDR
While the main era of β-lactam discovery programs is over, these agents continue to be the most widely prescribed antimicrobials in both community and hospital settings, resulting in a literal explosion of new β- lactamase variants of existing enzyme classes.
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TLDR
Extended-spectrum,-lactamases were first recognized in Europe, have become increasingly prevalent there, and are being reported around the world, including many sites in the United States.
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TLDR
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