ExsA and LcrF recognize similar consensus binding sites, but differences in their oligomeric state influence interactions with promoter DNA.

@article{King2013ExsAAL,
  title={ExsA and LcrF recognize similar consensus binding sites, but differences in their oligomeric state influence interactions with promoter DNA.},
  author={Jessica M. King and Sara Schesser Bartra and Gregory V. Plano and Timothy L. Yahr},
  journal={Journal of bacteriology},
  year={2013},
  volume={195 24},
  pages={
          5639-50
        }
}
  • Jessica M. King, Sara Schesser Bartra, +1 author Timothy L. Yahr
  • Published in Journal of bacteriology 2013
  • Biology, Medicine
  • ExsA activates type III secretion system (T3SS) gene expression in Pseudomonas aeruginosa and is a member of the AraC family of transcriptional regulators. AraC proteins contain two helix-turn-helix (HTH) DNA binding motifs. One helix from each HTH motif inserts into the major groove of the DNA to make base-specific contacts with the promoter region. The amino acids that comprise the HTH motifs of ExsA are nearly identical to those in LcrF/VirF, the activators of T3SS gene expression in the… CONTINUE READING

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