Exquisite delineation of 5-HT1A receptors in human brain with PET and [carbonyl-11 C]WAY-100635.

@article{Pike1996ExquisiteDO,
  title={Exquisite delineation of 5-HT1A receptors in human brain with PET and [carbonyl-11 C]WAY-100635.},
  author={Victor W. Pike and Julie A. McCarron and Adriaan A. Lammertsma and Safiye Osman and S. P. Hume and Peter A Sargent and C. J. Bench and Ian A Cliffe and Allan Fletcher and Paul M. Grasby},
  journal={European journal of pharmacology},
  year={1996},
  volume={301 1-3},
  pages={R5-7}
}
The 5-HT1A receptor antagonist, WAY-100635 [N-(2-(4-(2-methoxyphenyl)- 1-piperazinyl)ethyl)-N-(2-pyridyl) cyclohexanecarboxamide], was labelled in its carbonyl group with carbon-11 (t1/2 = 20.4 min), injected intravenously into healthy male volunteers and studied with positron emission tomography (PET). The acquired data provide exquisite delineation of 5-HT1A receptors in brain, with the ratio of radioactivity uptake in receptor-rich regions, such as medial temporal cortex, to that in receptor… CONTINUE READING