Expressions of angiopoietins and Tie2 in human choroidal neovascular membranes.

  title={Expressions of angiopoietins and Tie2 in human choroidal neovascular membranes.},
  author={Atsushi Otani and Hitoshi Takagi and Hideyasu Oh and Shinji Koyama and Miyo Matsumura and Y. Hasegawa Honda},
  journal={Investigative ophthalmology & visual science},
  volume={40 9},
PURPOSE To elucidate the potential role of angiopoietins and the Tie2 system in choroidal neovascularization. METHODS Surgically excised choroidal neovascular membranes (CNVMs) were obtained at vitrectomy from five eyes with age-related macular degeneration, three eyes with idiopathic neovascular maculopathy, and two eyes had degenerative myopia and two eyes had angioid streaks. Light microscopic immunohistochemistry was performed to detect cytokines such as vascular endothelial growth factor… CONTINUE READING


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Vascular endothelial growth factor (VEGF) and hypoxia regulate angiopoietin2 expression in retinal vascular endothelial cells

  • H Oh, H Takagi, K Suzuma, A Otani, Y. Honda
  • J Biol Chem
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