Expressions of DNA topoisomerase I and II gene and the genes possibly related to drug resistance in human myeloma cells.

@article{Ishikawa1993ExpressionsOD,
  title={Expressions of DNA topoisomerase I and II gene and the genes possibly related to drug resistance in human myeloma cells.},
  author={Hideki Ishikawa and Michio M. Kawano and Kosuke Okada and Hideyuki Tanaka and Osamu Tanabe and A T Sakai and Hideki Asaoku and K Iwato and Masaharu Nobuyoshi and Atsushi Kuramoto},
  journal={British journal of haematology},
  year={1993},
  volume={83 1},
  pages={
          68-74
        }
}
In order to clarify the mechanism of drug resistance in human myeloma cells, we investigated the expressions of DNA topoisomerase I and topoisomerase II gene and the genes possibly related to drug resistance; multi-drug resistant gene 1 (MDR-1), glutathione S-transferase class pi gene (GST-pi), by Northern blotting. Myeloma cells in eight of 15 cases prior to chemotherapy expressed topoisomerase I mRNA considerably, while the expression of topoisomerase II mRNA was detected weakly in only one… CONTINUE READING

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