Expression trapping: identification of novel genes expressed in hematopoietic and endothelial lineages by gene trapping in ES cells.

@article{Stanford1998ExpressionTI,
  title={Expression trapping: identification of novel genes expressed in hematopoietic and endothelial lineages by gene trapping in ES cells.},
  author={William L. Stanford and Georgina Caruana and Katherine Anne Vallis and Maneesha Inamdar and Michihiro Hidaka and Victoria L Bautch and Alan Bernstein},
  journal={Blood},
  year={1998},
  volume={92 12},
  pages={4622-31}
}
We have developed a large-scale, expression-based gene trap strategy to perform genome-wide functional analysis of the murine hematopoietic and vascular systems. Using two different gene trap vectors, we have isolated embryonic stem (ES) cell clones containing lacZ reporter gene insertions in genes expressed in blood island and vascular cells, muscle, stromal cells, and unknown cell types. Of 79 clones demonstrating specific expression patterns, 49% and 16% were preferentially expressed in… CONTINUE READING

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Gene trap characterization of Aquarius, a novel gene with RNA-dependent RNA polymerase motif

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