Expression systems for cloned xenobiotic transporters.

  title={Expression systems for cloned xenobiotic transporters.},
  author={John B. Pritchard and David Scott Miller},
  journal={Toxicology and applied pharmacology},
  volume={204 3},
One challenge of modern biology is to be able to match genes and their encoded proteins with events at the molecular, cellular, tissue, and organism levels, and thus, provide a multi-level understanding of gene function and dysfunction. How well this can be done for xenobiotic transporters depends on a knowledge of the genes expressed in the tissue, the cellular locations of the gene products (do they function for uptake or efflux?), and our ability to match substrates with transporters using… CONTINUE READING