Expression studies in gliomas and glial cells do not support a tumor suppressor role for LGI1.

@article{Piepoli2006ExpressionSI,
  title={Expression studies in gliomas and glial cells do not support a tumor suppressor role for LGI1.},
  author={Tiziana Piepoli and Cemile Jakupoglu and Wenli Gu and Elena Lualdi and Blanca Su{\'a}rez-Merino and Pietro Luigi Poliani and Maria Grazia Cattaneo and Barbara Ortino and Dorota Goplen and Jian Wang and Rosa Mola and Francesca Inverardi and Carolina Frassoni and Rolf Bjerkvig and Ortrud K Steinlein and Lucia Maria Vicentini and Oliver Bruestle and Gaetano Finocchiaro},
  journal={Neuro-oncology},
  year={2006},
  volume={8 2},
  pages={96-108}
}
Disruptions of LGI1 in glioblastoma (GBM) cell lines and LGI1 mutations in families with autosomal dominant epilepsy imply a role for LGI1 in glial cells as well as in neurons. Although we and others could not find LGI1 mutations in malignant gliomas, our initial studies appeared to support the idea that LGI1 is poorly expressed or absent in these tumors. Microarray data suggested that LGI1 could be involved in the control of matrix metalloproteinases, and we found that tumors derived from U87… CONTINUE READING
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