Expression studies and mutational analysis of the androgen regulated homeobox gene NKX3.1 in benign and malignant prostate epithelium.

@article{Ornstein2001ExpressionSA,
  title={Expression studies and mutational analysis of the androgen regulated homeobox gene NKX3.1 in benign and malignant prostate epithelium.},
  author={David K. Ornstein and Mario Cinquanta and Sigrid Weiler and Paul H. Duray and Michael R. Emmert-Buck and Cathy D. Vocke and W. Marston Linehan and James A. Ferretti},
  journal={The Journal of urology},
  year={2001},
  volume={165 4},
  pages={1329-34}
}
PURPOSE The NKX-3.1gene is an androgen regulated prostate specific homeobox gene that is believed to have a vital role in normal prostate development. In mice the homologue NKx3.1 is exclusively expressed in prostate epithelium. In humans NKX3.1 expression is also restricted to the prostate but to our knowledge the cellular location has not been described. Furthermore, since NKX3.1 maps to chromosomal band 8p21, a region with high loss of heterozygosity in prostate cancer, the gene has been… CONTINUE READING

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