Expression profiling reveals novel pathways in the transformation of melanocytes to melanomas.

@article{Hoek2004ExpressionPR,
  title={Expression profiling reveals novel pathways in the transformation of melanocytes to melanomas.},
  author={Keith Hoek and David L. Rimm and Kenneth R. Williams and Hongyu Zhao and Stephan Ariyan and Aiping Lin and Harriet M. Kluger and Aaron J. Berger and Elaine H. C. Cheng and Eduardo S Trombetta and Terence Wu and Michio Niinobe and Kazuaki Yoshikawa and Gregory Edward Hannigan and Ruth Halaban},
  journal={Cancer research},
  year={2004},
  volume={64 15},
  pages={
          5270-82
        }
}
Affymetrix and spotted oligonucleotide microarrays were used to assess global differential gene expression comparing normal human melanocytes with six independent melanoma cell strains from advanced lesions. The data, validated at the protein level for selected genes, confirmed the overexpression in melanoma cells relative to normal melanocytes of several genes in the growth factor/receptor family that confer growth advantage and metastasis. In addition, novel pathways and patterns of… CONTINUE READING
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