Expression profiling reveals meiotic male germ cell mRNAs that are translationally up- and down-regulated.

@article{Iguchi2006ExpressionPR,
  title={Expression profiling reveals meiotic male germ cell mRNAs that are translationally up- and down-regulated.},
  author={Naoko Iguchi and John W Tobias and Norman B. Hecht},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2006},
  volume={103 20},
  pages={7712-7}
}
Gametes rely heavily on posttranscriptional control mechanisms to regulate their differentiation. In eggs, maternal mRNAs are stored and selectively activated during development. In the male, transcription ceases during spermiogenesis, necessitating the posttranscriptional regulation of many paternal mRNAs required for spermatozoan assembly and function. To date, most of the testicular mRNAs known to be translationally regulated are initially transcribed in postmeiotic cells. Because protein… CONTINUE READING

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