Expression profiling of the influence of RAS mutants on the TGFB1-induced phenotype of the pancreatic cancer cell line PANC-1.

@article{Fensterer2004ExpressionPO,
  title={Expression profiling of the influence of RAS mutants on the TGFB1-induced phenotype of the pancreatic cancer cell line PANC-1.},
  author={Heiko Fensterer and Klaudia Giehl and Malte Buchholz and Volker Ellenrieder and Anita Buck and Hans Armin Kestler and Guido Adler and Peter Gierschik and Thomas M. Gress},
  journal={Genes, chromosomes & cancer},
  year={2004},
  volume={39 3},
  pages={
          224-35
        }
}
Expression profiling analyses were used to elucidate the functional relevance of RAS proteins in mediating the effect of TGFB1 on the transcriptional phenotype of the pancreatic cancer cell line PANC-1. Despite the presence of one mutated KRAS2 allele in parental PANC-1 pancreatic cancer cells, RAS-dependent signal transduction remained susceptible to stimulation by EGF and TGFB1. To analyze the impact of RAS proteins on the TGFB1-induced transcriptional phenotype, we used PANC-1 cells stably… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 18 CITATIONS

Caffeic Acid Phenethyl Ester Inhibits Epithelial-Mesenchymal Transition of Human Pancreatic Cancer Cells

  • Evidence-based complementary and alternative medicine : eCAM
  • 2013
VIEW 1 EXCERPT
CITES BACKGROUND