Expression profiling of synaptic microRNAs from the adult rat brain identifies regional differences and seizure-induced dynamic modulation.

@article{PichardoCasas2012ExpressionPO,
  title={Expression profiling of synaptic microRNAs from the adult rat brain identifies regional differences and seizure-induced dynamic modulation.},
  author={Israel Pichardo-Casas and Loyal A Goff and Mavis R. Swerdel and Alejandro Athie and Jonathan L. Davila and Mariana Ramos-Brossier and Martha Lapid-Volosin and Wilma J Friedman and Ronald P. Hart and Luis Vaca},
  journal={Brain research},
  year={2012},
  volume={1436},
  pages={20-33}
}
In recent years, microRNAs or miRNAs have been proposed to target neuronal mRNAs localized near the synapse, exerting a pivotal role in modulating local protein synthesis, and presumably affecting adaptive mechanisms such as synaptic plasticity. In the present study we have characterized the distribution of miRNAs in five regions of the adult mammalian brain and compared the relative abundance between total fractions and purified synaptoneurosomes (SN), using three different methodologies. The… CONTINUE READING

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