Expression profiling of metastatic renal cell carcinoma using gene set enrichment analysis

  title={Expression profiling of metastatic renal cell carcinoma using gene set enrichment analysis},
  author={Matthias Maruschke and Oliver Hakenberg and Dirk Koczan and Wolfgang Zimmermann and Christian G. Stief and Alexander Buchner},
  journal={International Journal of Urology},
To identify complex changes in cell biology occurring during metastatic progression of renal cell carcinoma using a novel gene expression analysis algorithm. 

P-cadherin: a useful biomarker for axillary-based breast cancer decisions in the clinical practice

The results indicate for the first time that the evaluation of P-cadherin expression in lymph node metastases is an important predictor of disease outcome, being a putative valuable marker for axillary-based breast cancer decisions in the clinical practice.

Multi-staged gene expression profiling reveals potential genes and the critical pathways in kidney cancer

It is concluded that among the most dominantly altered pathways for renal cell carcinoma, are PI3K-Akt, Foxo, endocytosis, MAPK, Tight junction, cytokine-cytokine receptor interaction pathways and the major source of alteration for these pathways are MAP3K13, CHAF1A, FDX1, ARHGAP26, ITGBL1, C10orf118.

Metastasis-Initiating Cells in Renal Cancer

Understanding the molecular phenotypes of metastasis-initiating cells (MICs) in renal cancer could play a vital role in developing strategies for therapeutic interventions in renal cancers.

A mosaic renal myeloid subtype with T-cell inhibitory and protumoral features is linked to immune escape and survival in clear cell renal cell cancer

It is described that ercDCs exhibit a distinct polarization state imparted by tissue-specific signals characteristic for RCC and renal tissue homeostasis, and a myeloid cell type with mosaic feature including tumor-promotion and immunoinhibition in human clear cell renal cell carcinoma.

β-catenin links von Hippel-Lindau to aurora kinase A and loss of primary cilia in renal cell carcinoma.

A role for β-catenin in regulating AURKA and formation of primary cilia in the setting of VHL deficiency is defined, opening new avenues for treatment with β- catenin inhibitors to rescue ciliogenesis in ccRCC.

BAGSE: a Bayesian hierarchical model approach for gene set enrichment analysis

The proposed Bayesian Analysis of Gene Set Enrichment (BAGSE) is a novel computational method built on a Bayesian hierarchical model and fully accounts for the uncertainty embedded in the association evidence of individual genes that is effective in aiding the discovery of potentially causal pathways and gene networks.



Gene expression analysis in clear cell renal cell carcinoma using gene set enrichment analysis for biostatistical management

It’s shown that direct hits to the immune system are more likely to be associated with dementia than other types of injuries, including gunshot wounds.

Glutathione S‐transferases as molecular markers of tumour progression and prognosis in renal cell carcinoma

Searchfield L, Price S A, Betton G, Jasani B, Riccardi D & Griffiths D F R
(2011) Histopathology58, 180–190
Glutathione S‐transferases as molecular markers of tumour progression and prognosis in

Gene Signatures of Progression and Metastasis in Renal Cell Cancer

The gene expression of primary tumors provides us information about the metastatic status in the respective patients and has the potential, if prospectively validated, to enrich the armamentarium of diagnostic tests in RCC.

Clear Cell Renal Cell Carcinoma: Gene Expression Analyses Identify a Potential Signature for Tumor Aggressiveness

The data indicate that the gene expression alterations that result in aggressive behavior and metastatic potential can be identified in the primary tumor.

Expression of aurora kinase A is associated with metastasis-free survival in node-negative breast cancer patients

AURKA is associated with worse prognosis in estrogen receptor positive breast carcinomas and patients with the highest AURKA expression have a particularly bad prognosis and may profit from therapy with AURka inhibitors.

Aurora kinase A as a rational target for therapy in glioblastoma.

Relative expression of AURKA may be of prognostic value and warrants further investigation with larger, prospective studies, and Pharmacological inhibition of AurKA is a potentially promising therapy for glioblastoma.

The changing pattern of kidney cancer incidence and mortality in Europe

To update trends in kidney cancer mortality in 32 European countries and the European Union (EU) as a whole, as mortality from kidney cancer has increased throughout Europe until the late 1980s or

Novel approaches in the therapy of metastatic renal cell carcinoma

An update on current therapeutic approaches and targeted molecular therapy for metastatic RCC is provided to provide an update on the development of new therapies based on molecular targeting.

Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles

It is demonstrated how the GSEA method yields insights into several cancer-related data sets, including leukemia and lung cancer, where single-gene analysis finds little similarity between two independent studies of patient survival in lung cancer.