Expression profiling of chicken DT40 lymphoma cells indicates clonal selection of knockout and gene reconstituted cells.


The DT40 cell-line has been extensively used to create deletion mutants, one of which lacks Bruton's tyrosine kinase (Btk). Btk is a cytoplasmic tyrosine kinase important for B-lymphocyte maturation. It was previously shown that there are differences in gene expression between wild-type and Btk-deficient animals. Global gene expression profiling of the… (More)
DOI: 10.1016/j.bbrc.2008.10.040