Expression profiling of archival tumors for long-term health studies.

  title={Expression profiling of archival tumors for long-term health studies.},
  author={Levi Waldron and Shuji Ogino and Yujin Hoshida and Kaori Shima and Amy E McCart Reed and Peter T. Simpson and Yoshifumi Baba and Katsuhiko Nosho and Nicola Segata and Ana Cristina Vargas and Margaret C. Cummings and Sunil R Lakhani and Gregory J. Kirkner and Edward L. Giovannucci and John Quackenbush and Todd R. Golub and Charles S. Fuchs and Giovanni Parmigiani and Curtis Huttenhower},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  volume={18 22},
PURPOSE More than 20 million archival tissue samples are stored annually in the United States as formalin-fixed, paraffin-embedded (FFPE) blocks, but RNA degradation during fixation and storage has prevented their use for transcriptional profiling. New and highly sensitive assays for whole-transcriptome microarray analysis of FFPE tissues are now available, but resulting data include noise and variability for which previous expression array methods are inadequate. EXPERIMENTAL DESIGN We… CONTINUE READING
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Gene expression profiles from formalin fixed paraffin embedded breast cancer tissue are largely comparable to fresh frozen matched tissue

  • L Mittempergher, JJ de Ronde, NieuwlandM, RM Kerkhoven, I Simon, EJ Th. Rutgers
  • PLoS ONE 2011;6:e17163-e
  • 2011
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