Expression profiling of Wilms tumors reveals new candidate genes for different clinical parameters.

@article{Zirn2006ExpressionPO,
  title={Expression profiling of Wilms tumors reveals new candidate genes for different clinical parameters.},
  author={Birgit Zirn and Olivier Hartmann and Birgit Samans and Michael Krause and Stefanie Wittmann and Fredrik Mertens and Norbert Graf and Martin Eilers and Manfred Gessler},
  journal={International journal of cancer},
  year={2006},
  volume={118 8},
  pages={1954-62}
}
Wilms tumor is the most frequent renal neoplasm in children, but our understanding of its genetic basis is still limited. We performed cDNA microarray experiments using 63 primary Wilms tumors with the aim of detecting new candidate genes associated with malignancy grade and tumor progression. All tumors had received preoperative chemotherapy as mandated by the SIOP protocol, which sets this study apart from related approaches in the Unites States that are based on untreated samples. The… CONTINUE READING