Expression profiling of EWS/FLI identifies NKX2.2 as a critical target gene in Ewing's sarcoma.

  title={Expression profiling of EWS/FLI identifies NKX2.2 as a critical target gene in Ewing's sarcoma.},
  author={Richard A. G. Smith and Leah A. Owen and Deborah J Trem and Jenny S Wong and Jennifer S. Whangbo and Todd R. Golub and Stephen L Lessnick},
  journal={Cancer cell},
  volume={9 5},
Our understanding of Ewing's sarcoma development mediated by the EWS/FLI fusion protein has been limited by a lack of knowledge regarding the tumor cell of origin. To circumvent this, we analyzed the function of EWS/FLI in Ewing's sarcoma itself. By combining retroviral-mediated RNA interference with reexpression studies, we show that ongoing EWS/FLI expression is required for the tumorigenic phenotype of Ewing's sarcoma. We used this system to define the full complement of EWS/FLI-regulated… CONTINUE READING
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