Expression profiling identifies three pathways altered in cellular immortalization: interferon, cell cycle, and cytoskeleton.

@article{Fridman2006ExpressionPI,
  title={Expression profiling identifies three pathways altered in cellular immortalization: interferon, cell cycle, and cytoskeleton.},
  author={Aviva Levine Fridman and Lin Tang and Olga I. Kulaeva and Bin Ye and Qunfang Li and Fatimah A Nahhas and Paul C. Roberts and Susan J. Land and Judith Abrams and Michael A. Tainsky},
  journal={The journals of gerontology. Series A, Biological sciences and medical sciences},
  year={2006},
  volume={61 9},
  pages={
          879-89
        }
}
Abrogation of cellular senescence, resulting in immortalization, is a necessary step in the tumorigenic transformation of a cell. Four independent, spontaneously immortalized Li-Fraumeni syndrome (LFS) cell lines were used to analyze the gene expression changes that may have given these cell lines the growth advantage required to become immortal. A cellular senescence-like phenotype can be induced in immortal LFS cells by treating them with the DNA methyltransferase (DNMT) inhibitor 5-aza… CONTINUE READING
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