Expression profiling identifies strain-specific changes associated with ethanol withdrawal in mice.

@article{Daniels2002ExpressionPI,
  title={Expression profiling identifies strain-specific changes associated with ethanol withdrawal in mice.},
  author={Gwynn M Daniels and Kari J. Buck},
  journal={Genes, brain, and behavior},
  year={2002},
  volume={1 1},
  pages={35-45}
}
Mice that exhibit characteristics of physical dependence following ethanol exposure serve as useful models of alcoholism in humans. The DBA/2J and C57BL/6J inbred strains differ in their behavioral response to ethanol withdrawal. Alterations in gene expression are believed to underlie neuroadaptation to ethanol dependence and tolerance. Therefore, the differences in ethanol withdrawal severity observed between the DBA/2J and C57BL/6J strains may be related to differential regulation of gene… CONTINUE READING

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