Expression profiling and identification of potential molecular targets for therapy in pulmonary large-cell neuroendocrine carcinoma.

@article{Iyoda2011ExpressionPA,
  title={Expression profiling and identification of potential molecular targets for therapy in pulmonary large-cell neuroendocrine carcinoma.},
  author={Akira Iyoda and William D Travis and Inderpal S. Sarkaria and S X Jiang and Hideki Amano and Yuichi Sato and Makoto Saegusa and Valerie Rusch and Yukitoshi Satoh},
  journal={Experimental and therapeutic medicine},
  year={2011},
  volume={2 6},
  pages={1041-1045}
}
The prognosis for patients with large-cell neuroendocrine carcinoma (LCNEC) of the lung is extremely poor, and an optimal treatment has not yet been established. It has been recently reported that molecular-targeted therapies, such as tyrosine kinase inhibitors for epidermal growth factor receptor (EGFR), are effective in patients with lung carcinoma. In efforts to improve the prognosis of patients with LCNEC, we analyzed gene expression, gene mutations and immunohistochemical (IHC) expression… CONTINUE READING
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