Expression profiling analyses of gonadotropin responses and tumor development in the absence of inhibins.

@article{Burns2003ExpressionPA,
  title={Expression profiling analyses of gonadotropin responses and tumor development in the absence of inhibins.},
  author={Kathleen H. Burns and Gabe E Owens and Samuel C Ogbonna and John H. Nilson and Martin M. Matzuk},
  journal={Endocrinology},
  year={2003},
  volume={144 10},
  pages={4492-507}
}
Transgenic mice with engineered disruptions in bidirectional endocrine signaling between the pituitary and gonad have shed light on the specific effects of the loss of function of gonadotropins and inhibins. These models are valuable tools for studying ovarian biology because they phenocopy specific pathological states and have variations in ovarian tissue composition that allow us to identify genes expressed in specific cell types. We have used emerging mRNA expression profiling technologies… CONTINUE READING