Expression profiles of multiple genes in single neurons of Alzheimer's disease.

  title={Expression profiles of multiple genes in single neurons of Alzheimer's disease.},
  author={Nienwen Chow and Charles T Cox and Linda M. Callahan and Jill M Weimer and Linsheng Guo and Paul D. Coleman},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={95 16},
Many changes have been described in the brains of Alzheimer's disease (AD) patients, including loss of neurons and formation of senile plaques and neurofibrillary tangles. The molecular mechanisms underlying these pathologies are unclear. Northern blot, dot-blot, and reverse transcription-coupled PCR analyses have demonstrated altered expression levels of multiple messages in AD brain. Because not all cells are equally affected by the disease, these methods obviously cannot study the changes in… CONTINUE READING
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