Expression profiles of miRNAs from bovine mammary glands in response to Streptococcus agalactiae-induced mastitis

@article{Pu2017ExpressionPO,
  title={Expression profiles of miRNAs from bovine mammary glands in response to Streptococcus agalactiae-induced mastitis},
  author={Junhua Pu and Rui Li and Chenglong Zhang and Dan Chen and Xiangxiang Liao and Yihui Zhu and Xiaohan Geng and De-jun Ji and Yongjiang Mao and Yunchen Gong and Zhangping Yang},
  journal={Journal of Dairy Research},
  year={2017},
  volume={84},
  pages={300 - 308}
}
This study aimed to describe the expression profiles of microRNAs (miRNAs) from mammary gland tissues collected from dairy cows with Streptococcus agalactiae-induced mastitis and to identify differentially expressed miRNAs related to mastitis. The mammary glands of Chinese Holstein cows were challenged with Streptococcus agalactiae to induce mastitis. Small RNAs were isolated from the mammary tissues of the test and control groups and then sequenced using the Solexa sequencing technology to… 
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Methods Citations
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20 Citations

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Citation Type

Integrative Analysis of miRNA and mRNA Expression Profiles in Mammary Glands of Holstein Cows Artificially Infected with Staphylococcus aureus
TLDR
Findings could enhance the understanding of the underlying immune response in bovine mammary glands against S. aureus infection and provide a useful foundation for future application of the miRNA–mRNA-based genetic regulatory network in the breeding cows resistant to S.Aureus.
Bovine milk transcriptome analysis reveals microRNAs and RNU2 involved in mastitis
TLDR
The genome‐wide analysis of miRNA profiles in this study provides insight into bovine mastitis and inflammatory diseases.
Screening candidate microR-15a- IRAK2 regulatory pairs for predicting the response to Staphylococcus aureus-induced mastitis in dairy cows
TLDR
It is concluded that miR-15a and miR -15a target genes (IRAK2) constitute potential miRNA–mRNA regulatory pairs for use as biomarkers to predict a mastitis response.
Expression profiling of microRNAs in the Mycoplasma bovis infected mammary gland tissue in Holstein Friesian cattle.
Comprehensive MicroRNA Expression Profile of the Mammary Gland in Lactating Dairy Cows With Extremely Different Milk Protein and Fat Percentages
TLDR
Gene ontology and KEGG pathway analyses showed that these targets were enriched for functions such as metabolism of protein and fat, and development of mammary gland, which indicating the critical role of these miRNAs in regulating the formation of milk protein andfat.
Characterization of miRNA profiles in the mammary tissue of dairy cattle in response to heat stress
TLDR
Deep RNA sequencing analysis indicated that the differentially expressed miRNAs identified in this study may act as dominant regulators during heat stress and reduce heat stress damage of Holstein cows by up-regulating or down- Regulating these differentially expression miRN as well as targeted genes.
Small RNA deep sequencing reveals the expressions of microRNAs in ovine mammary gland development at peak-lactation and during the non-lactating period.
Bovine serum miR-21 expression affected by mastitis.
Genome-Wide DNA Methylation Analysis of Mammary Gland Tissues From Chinese Holstein Cows With Staphylococcus aureus Induced Mastitis
TLDR
A genome-wide DNA methylation profile of the mammary gland of Chinese Holstein cows following experimentally induced S. aureus mastitis is constructed and serves as a reference for future epigenetic regulation and mechanistic studies.
Proteomics study on the protective mechanism of soybean isoflavone against inflammation injury of bovine mammary epithelial cells induced by Streptococcus agalactiae
TLDR
The anti-inflammatory effect of soybean isoflavones (SI) on the inflammatory response induced by Streptococcus agalactiae of bovine mammary epithelial cells (bMECs) was verified and proteomics results showed that 133 proteins were up-regulated and 89 proteins were down-regulated significantly.
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