Expression profiles of PERIOD1, 2, and 3 in peripheral blood mononuclear cells from older subjects.

@article{Hida2009ExpressionPO,
  title={Expression profiles of PERIOD1, 2, and 3 in peripheral blood mononuclear cells from older subjects.},
  author={Akiko Hida and Hiroaki Kusanagi and Kohtoku Satoh and Tomonori Kato and Yasuhiro Matsumoto and Masaru Echizenya and Tetsuo Shimizu and Shigekazu Higuchi and Kazuo Mishima},
  journal={Life sciences},
  year={2009},
  volume={84 1-2},
  pages={33-7}
}
AIMS Circadian clocks regulate daily rhythms of behavior and physiology such as the sleep-wake cycle and hormonal secretion. Numerous characteristics of the behavioral and physiological processes change with age. In this study, we evaluated the circadian clockwork in older people by measuring daily profiles of PERIOD (PER) gene expression in peripheral blood mononuclear cells (PBMCs). MAIN METHODS Blood samples were collected from 6 healthy older subjects (mean age 62 years) at 2-h intervals… CONTINUE READING

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