Expression profile of the polycomb group protein enhancer of Zeste homologue 2 and its prognostic relevance in renal cell carcinoma.

@article{Hinz2009ExpressionPO,
  title={Expression profile of the polycomb group protein enhancer of Zeste homologue 2 and its prognostic relevance in renal cell carcinoma.},
  author={Stefan Hinz and Steffen Weikert and Ahmed Magheli and Mich{\`e}le J Hoffmann and Rainer Engers and Kurt Miller and Carsten Kempkensteffen},
  journal={The Journal of urology},
  year={2009},
  volume={182 6},
  pages={2920-5}
}
PURPOSE EZH2 increases the proliferation rate and apoptosis resistance of renal cell carcinoma cell lines. To date its clinical impact on the outcome in patients with renal cell carcinoma is not known. To our knowledge this is the first study of the association of EZH2 expression with histopathological features and disease outcomes in a large cohort of patients who underwent surgery for renal cell carcinoma. MATERIALS AND METHODS Real-time reverse transcriptase-polymerase chain reaction was… CONTINUE READING

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