Expression profile of proteins involved in scar formation in the healing process of full-thickness excisional wounds in the porcine model.

@article{Ulrich2007ExpressionPO,
  title={Expression profile of proteins involved in scar formation in the healing process of full-thickness excisional wounds in the porcine model.},
  author={Magda M W Ulrich and Michelle Verkerk and Linda Reijnen and Marcel Vlig and Antoon J. van den Bogaerdt and Esther Middelkoop},
  journal={Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society},
  year={2007},
  volume={15 4},
  pages={482-90}
}
Scar formation in deep dermal wounds is associated with excessive collagen deposition and contraction. Increased collagen synthesis and decreased collagen degradation are the mechanisms through which this form of fibrosis can occur. Another factor might be a different kind of collagen cross-linking seen in fibrotic skin diseases. This type of cross-linking is dependent on the enzyme lysyl hydroxylase-2b. In this study, we examined the expression profile of the potential key players in scar… CONTINUE READING
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