Expression profile analysis of microRNAs in prostate cancer by next-generation sequencing.

  title={Expression profile analysis of microRNAs in prostate cancer by next-generation sequencing.},
  author={Chunjiao Song and Huan Chen and Tingzhang Wang and Weiguang Zhang and Guomei Ru and Juan Lang},
  journal={The Prostate},
  volume={75 5},
BACKGROUND Prostate cancer (PCa) is the second leading cause of tumor mortality among males in western societies. In China, the diagnostic and fatality rate of PCa is increasing yearly. METHODS To characterize underlying molecular mechanisms, the microRNA (miRNA) profile of high-grade PCa, low-grade PCa, and benign prostate hyperplasia (BPH) were compared using high-throughput Illumina sequencing and quantitative real-time PCR (qRT-PCR) methods. Moreover, a variety of biological information… CONTINUE READING
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