Expression patterns of odorant receptors and response properties of olfactory sensory neurons in aged mice.

@article{Lee2009ExpressionPO,
  title={Expression patterns of odorant receptors and response properties of olfactory sensory neurons in aged mice.},
  author={Anderson C. Lee and Huikai Tian and Xavier Grosmaitre and Minghong Ma},
  journal={Chemical senses},
  year={2009},
  volume={34 8},
  pages={695-703}
}
The sense of smell deteriorates in normal aging, but the underling mechanisms are still elusive. Here we investigated age-related alterations in expression patterns of odorant receptor (OR) genes and functional properties of olfactory sensory neurons (OSNs)-2 critical factors that define the odor detection threshold in the olfactory epithelium. Using in situ hybridization for 9 representative OR genes, we compared the cell densities of each OR in coronal nose sections at different ages (3-27… CONTINUE READING
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