Expression patterns of insulin-like growth factor binding protein isoforms in medulloblastoma subtypes and clinical correlation.

Abstract

BACKGROUND Insulin-like growth factor binding proteins (IGFBPs) are known to be differentially expressed in brain tumours. The role of some IGFBPs in malignant CNS tumours, except glioblastoma, is unknown. We evaluated the protein expression of 3 IGFBP isoforms (IGFBP-2, -3, -5) in medulloblastoma and correlated them with histological subtypes and clinical… (More)
DOI: 10.1159/000367926

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