Expression patterns of hypoxic markers at the invasive margin of colorectal cancers and liver metastases.

@article{Rajaganeshan2009ExpressionPO,
  title={Expression patterns of hypoxic markers at the invasive margin of colorectal cancers and liver metastases.},
  author={Raj Rajaganeshan and Ravi Prasad and Pierre Jos{\'e} Guillou and Nigel Scott and Graeme P Poston and David G. Jayne},
  journal={European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology},
  year={2009},
  volume={35 12},
  pages={1286-94}
}
AIM To understand the role of hypoxia in cancer progression of primary colorectal cancer and colorectal liver metastases. To look at associations of hypoxia with more aggressive phenotypes. METHODS Archival tissue was retrieved from 55 patients and tissue micro arrays were constructed using tissue from the margin and the centre of the tumour. Hypoxia markers Hif-1alpha, Vegf, CA-9, VHL and Glut-1 were visualised using immunohistochemical detection and quantified using semi-quantitative… CONTINUE READING

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