Expression patterns of connective tissue growth factor and of TGF-beta isoforms during glomerular injury recapitulate glomerulogenesis.

@article{Ito2010ExpressionPO,
  title={Expression patterns of connective tissue growth factor and of TGF-beta isoforms during glomerular injury recapitulate glomerulogenesis.},
  author={Yasuhiko Ito and Roel Goldschmeding and Hirotake Kasuga and Nike Claessen and Masahiro Nakayama and Yukio Yuzawa and Akiho Sawai and Tsuyoshi Watanabe and Jan J. Weening and Jan Aten},
  journal={American journal of physiology. Renal physiology},
  year={2010},
  volume={299 3},
  pages={
          F545-58
        }
}
Transforming growth factor (TGF)-beta(1), -beta(2), and -beta(3) are involved in control of wound repair and development of fibrosis. Connective tissue growth factor (CTGF) expression is stimulated by all TGF-beta isoforms and is abundant in glomerulosclerosis and other fibrotic disorders. CTGF is hypothesized to mediate profibrotic effects of TGF-beta(1) or to facilitate interaction of TGF-beta(1) with its receptor, but its interactions with TGF-beta isoforms in nonpathological conditions are… CONTINUE READING

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