Expression patterns of Jagged, Delta1, Notch1, Notch2, and Notch3 genes identify ligand-receptor pairs that may function in neural development.

@article{Lindsell1996ExpressionPO,
  title={Expression patterns of Jagged, Delta1, Notch1, Notch2, and Notch3 genes identify ligand-receptor pairs that may function in neural development.},
  author={Claire E. Lindsell and Jim Boulter and Guy Disibio and Achim Gossler and Gerry Weinmaster},
  journal={Molecular and cellular neurosciences},
  year={1996},
  volume={8 1},
  pages={14-27}
}
Notch genes encode receptors for a signaling pathway that regulates neurogenesis. The DSL (Delta/Serrate/lag-2) genes encode ligands that bind and activate Notch. In situ hybridization was used to determine the spatiotemporal expression of Notch1, Notch2, and Notch3, and the DSL ligands, Jagged and Delta 1, in an effort to identify potential ligand-receptor pairs that function during development of the rat nervous system. Here we describe both distinct and overlapping expression patterns for… CONTINUE READING
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