Expression pattern of fibroblast growth factors (FGFs), their receptors and antagonists in primary endothelial cells and vascular smooth muscle cells

  title={Expression pattern of fibroblast growth factors (FGFs), their receptors and antagonists in primary endothelial cells and vascular smooth muscle cells},
  author={Marianne Antoine and Werner Wirz and Carmen Gabriele Tag and M. Mavituna and Neil Emans and Thomas Korff and Volker R. Stoldt and Axel M. Gressner and P. E. Kiefer},
  journal={Growth Factors},
  pages={87 - 95}
Fibroblast growth factors (FGFs) are important angiogenic growth factors. While basic FGF (FGF2) is well established as a potent inducer of angiogenesis much less is known about other FGFs possibly expressed by EC. We investigated the expression of all known FGFs, their main tyrosine kinase receptors and antagonists by RT-PCR analysis in human umbilical vascular endothelial cells (HUVECs) to obtain a complete expression profile of this important growth factor system in model endothelial cells… 
Non-canonical fibroblast growth factor signalling in angiogenesis.
Recent findings related to non-canonical FGF signalling are discussed with emphasis on the endothelial biology and angiogenesis and gangliosides are implicated as a co-receptor system of FGFs.
Fibroblast Growth Factors and their Emerging Cancer-Related Aspects
Overexpression of FGFs and FGFRs has been correlated with advanced tumor forms, mainly prostate, mammary gland, bladder and renal cell carcinomas.
The potential of fibroblast growth factor/fibroblast growth factor receptor signaling as a therapeutic target in tumor angiogenesis
A compelling biologic rationale exists for the development of anti-FGF/FGFR agents for the inhibition of tumor angiogenesis in cancer therapy, including FGFR selective and nonselective small-molecule tyrosine kinase inhibitors, anti-FGFR antibodies, and FGF ligand traps.
Fibroblast Growth Factor Signaling in the Vasculature
A review of recent studies in which new and unanticipated roles for FGFs and their receptors in the vasculature have been revealed is summarized.
The Role of Fibroblast Growth Factor (FGF) Signaling in Tissue Repair and Regeneration
Several FGFs directly or indirectly interfere with repair during tissue regeneration, in addition to their critical functions in the maintenance of pluripotency and dedifferentiation of stem cells, are summarized.
New developments in the biology of fibroblast growth factors.
This review focuses on new developments in the FGF field since the last review in 2015, including the use of optogenetic tools, viral vectors, and inducible transgenes to experimentally modulate FGF signaling, the clinical use of small molecule FGFR inhibitors, and an expanded understanding of endocrine F GF signaling.
Fibroblast Growth Factor Signaling in Vascular Development
In the 1980s, fibroblast growth factor was recognized as an important endothelial cell mitogen and mediator of angiogenesis and is routinely used by numerous laboratories as proangiogenic stimuli, e.g. in the matrigel plug assay.
Syndecan 4 Regulates FGFR1 Signaling in Endothelial Cells by Directing Macropinocytosis
S4 is identified as a regulator of MAPK signaling and the question of how distinct classes of FGFRs individually contribute to signal transduction in endothelial cells is addressed, defining the mechanism by which FGFR1 and S4 coordinate downstream signaling upon FGF2 stimulation.


Paracrine and autocrine effects of fibroblast growth factor-4 in endothelial cells
Significant differences are observed in the biological behavior of FGF4 versus FGF2 transfectants, indicating that the expression of the various members of the FGF family can differently affect the behavior of endothelial cells and, possibly, of other cell types, including tumor cells.
Fibroblast growth factors, their receptors and signaling.
FGF signaling also appears to play a role in tumor growth and angiogenesis, and autocrine FGF signaling may be particularly important in the progression of steroid hormone-dependent cancers to a hormone-independent state.
Overlapping Expression and Redundant Activation of Mesenchymal Fibroblast Growth Factor (FGF) Receptors by Alternatively Spliced FGF-8 Ligands*
  • Allison G. Blunt, Avril Lawshé, Michael L. Cunningham, Marianne L. Seto, David M. Ornitz, Craig A. MacArthur
  • Biology
    The Journal of Biological Chemistry
  • 1997
Findings are consistent with the hypothesis that the multiple FGF-8 isoforms are functionally redundant and function to signal in paracrine (epithelial to mesenchymal) contexts.
Distinct role of fibroblast growth factor-2 and vascular endothelial growth factor on tumor growth and angiogenesis.
Fibroblast growth factor-18 is a trophic factor for mature chondrocytes and their progenitors.
Exposure of Fgf18 and the genes for two of its receptors in chondrocytes suggests that F gf18 may play an autocrine role in the biology of normal articular cartilage and demonstrates that FGF18 can act as a trophic factor for elastic chond rocytes and their progenitors in vivo and articular chondROcytes cultured in vitro.
Fibroblast Growth Factor-2 (FGF-2) Induces Vascular Endothelial Growth Factor (VEGF) Expression in the Endothelial Cells of Forming Capillaries: An Autocrine Mechanism Contributing to Angiogenesis
Angiogenesis in vivo can be modulated by a novel mechanism that involves the autocrine action of vascular endothelial cell-derived FGF-2 and VEGF and is demonstrated to be an important autocrine mediator of F GF-2-induced angiogenesis.
Fibroblast Growth Factor (FGF) Homologous Factors Share Structural but Not Functional Homology with FGFs*
It is shown that recombinant FHFs can bind heparin with high affinity like classical FGFs yet fail to activate any of the seven principal FGFRs, and it is demonstrated that FHFS bind IB2 directly, furthering the contention that F HFs and F GFs elicit their biological effects by binding to different protein partners.
Fibroblast growth factor homologous factors are intracellular signaling proteins