Expression pattern and ontogenesis of thyroid hormone receptor isoforms in the mouse heart.

@article{Stoykov2006ExpressionPA,
  title={Expression pattern and ontogenesis of thyroid hormone receptor isoforms in the mouse heart.},
  author={I. Stoykov and Behrouz Zandieh-Doulabi and Antoon F. M. Moorman and Vincent M Christoffels and Wilmar Maarten Wiersinga and Onno Bakker},
  journal={The Journal of endocrinology},
  year={2006},
  volume={189 2},
  pages={231-45}
}
Nuclear thyroid hormone (T3) receptors (TR) play a critical role in mediating the effects of T3 on development, differentiation and normal physiology of many organs. The heart is a major target organ of T3, and recent studies in knockout mice demonstrated distinct effects of the different TR isoforms on cardiac function, but the specific actions of TR isoforms and their specific localization in the heart remain unclear. We therefore studied the expression of TRalpha1, TRalpha2 and TRbeta1… CONTINUE READING