Expression of zinc-deficient human superoxide dismutase in <ce:italic>Drosophila</ce:italic> neurons produces a locomotor defect linked to mitochondrial dysfunction

@article{Bahadorani2013ExpressionOZ,
  title={Expression of zinc-deficient human superoxide dismutase in <ce:italic>Drosophila</ce:italic> neurons produces a locomotor defect linked to mitochondrial dysfunction},
  author={Sepehr Bahadorani and Spencer T Mukai and Jason Rabie and Joseph S. Beckman and Arthur J. Hilliker},
  journal={Neurobiology of Aging},
  year={2013},
  volume={34},
  pages={2322-2330}
}
More than 130 different mutations in the Cu/Zn superoxide dismutase (SOD1) gene have been associated with amyotrophic lateral sclerosis but the mechanism of this toxicity remains controversial. To gain insight into the importance of the zinc site in the pathogenesis of SOD1 in vivo, we generated a Drosophila model with transgenic expression of a zinc-deficient human SOD1. Expression of zinc-deficient SOD1 in Drosophila resulted in a progressive movement defect with associated mitochondrial… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 10 extracted citations

A fruitful endeavor: modeling ALS in the fruit fly.

Brain research • 2015
View 5 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…