• Biology, Medicine
  • Published in Development 1998

Expression of wingless in the Drosophila embryo: a conserved cis-acting element lacking conserved Ci-binding sites is required for patched-mediated repression.

@article{Lessing1998ExpressionOW,
  title={Expression of wingless in the Drosophila embryo: a conserved cis-acting element lacking conserved Ci-binding sites is required for patched-mediated repression.},
  author={Derek Lessing and Roeland Nusse},
  journal={Development},
  year={1998},
  volume={125 8},
  pages={
          1469-76
        }
}
Patterning of the Drosophila embryo depends on the accurate expression of wingless (wg), which encodes a secreted signal required for segmentation and many other processes. Early expression of wg is regulated by the nuclear proteins of the gap and pair-rule gene classes but, after gastrulation, wg transcription is also dependent on cell-cell communication. Signaling to the Wg-producing cells is mediated by the secreted protein, Hedgehog (Hh), and by Cubitus interruptus (Ci), a transcriptional… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 24 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 49 REFERENCES

The tumor suppressor gene

D. M. Stone
  • 1996

The tumor suppressor gene patched encodes a candidate receptor for Sonic hedgehog

D. B. Roberts, D. M. Stone
  • Nature
  • 1996