Expression of voltage-gated K+ channels in human atrium

  title={Expression of voltage-gated K+ channels in human atrium},
  author={Federica Bertaso and Claire C Sharpe and Bruce M. Hendry and Andrew F James},
  journal={Basic Research in Cardiology},
Voltage-gated K+ channels underlie repolarisation of the cardiac action potential and represent a potential therapeutic target in the treatment of cardiac dysrhythmias. However, very little is known about the relative expression of K+ channel subunits in the human myocardium. We used a semi-quantitative RT-PCR technique to examine the relative expression of mRNAs for the voltage-gated K+ channel subunits, Kv1.2, Kv1.4, Kv1.5, Kv2.1, Kv4.2, Kv4.3, KvLQT1, HERG and IsK in samples of human atrial… CONTINUE READING
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