Expression of viral polymerase and phosphorylation of core protein determine core and capsid localization of the human hepatitis B virus.


Biopsies from patients show that hepadnaviral core proteins and capsids - collectively called core - are found in the nucleus and cytoplasm of infected hepatocytes. In the majority of studies, cytoplasmic core localization is related to low viraemia while nuclear core localization is associated with high viral loads. In order to better understand the… (More)
DOI: 10.1099/vir.0.064816-0


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