Expression of vascular endothelial growth factor and its receptors in the central nervous system in amyotrophic lateral sclerosis.

@article{Brockington2006ExpressionOV,
  title={Expression of vascular endothelial growth factor and its receptors in the central nervous system in amyotrophic lateral sclerosis.},
  author={Alice Brockington and Stephen Barrie Wharton and Malee Fernando and Catherine H Gelsthorpe and Lynne M Baxter and Paul G. Ince and Claire E. Lewis and Pamela J Shaw},
  journal={Journal of neuropathology and experimental neurology},
  year={2006},
  volume={65 1},
  pages={26-36}
}
Vascular endothelial growth factor (VEGF) prolongs survival in the mutant SOD1 transgenic mouse model of amyotrophic lateral sclerosis (ALS), whereas dysregulation of VEGF through deletion of its hypoxia-regulatory element causes motor neuron degeneration in mice. We investigated the expression of VEGF and its major agonist receptors in the normal central nervous system and in patients with ALS. Immunohistochemistry demonstrated similar expression patterns of VEGF and VEGF receptor 2 (VEGFR2… CONTINUE READING
45 Extracted Citations
34 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 45 extracted citations

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 34 references

Molecular and cellular pathways of neurodegeneration in motor neurone disease

  • PJ Shaw
  • J Neurol Neurosurg Psychiatry
  • 2005
1 Excerpt

Similar Papers

Loading similar papers…