Expression of type 2 iodothyronine deiodinase in human osteoblast is stimulated by thyrotropin.

@article{Morimura2005ExpressionOT,
  title={Expression of type 2 iodothyronine deiodinase in human osteoblast is stimulated by thyrotropin.},
  author={Tadashi Morimura and Katsuhiko Tsunekawa and Takayuki Kasahara and Koji Seki and Takayuki Ogiwara and Masatomo Mori and Masami Murakami},
  journal={Endocrinology},
  year={2005},
  volume={146 4},
  pages={2077-84}
}
Thyroid hormones play important roles in bone growth, development, and turnover. To exert its biological activity, T(4) needs to be converted to T(3) by iodothyronine deiodinase. In human thyroid gland as well as rat brown adipose tissue, type 2 iodothyronine deiodinase (D2) expression is regulated by a TSH receptor-cAMP-mediated mechanism. TSH receptor knockout mice demonstrated the direct effects of TSH on bone via TSH receptors found on osteoblast and osteoclast precursors. In the present… CONTINUE READING
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