Expression of transforming growth factor-beta receptor type 1 and type 2 in human sporadic vestibular Schwannoma.

@article{Lttrich2007ExpressionOT,
  title={Expression of transforming growth factor-beta receptor type 1 and type 2 in human sporadic vestibular Schwannoma.},
  author={Mathias L{\"o}ttrich and Christian Mawrin and Kathrin Chamaon and E. J. F. Kirches and Knut Dietzmann and Bernd Freigang},
  journal={Pathology, research and practice},
  year={2007},
  volume={203 4},
  pages={245-9}
}
Expression of the transforming growth factor-beta (TGF-beta) protein family in the peripheral nervous system is well established, but the role of their cognate receptors TGF-beta receptor type 1 (R1) and type 2 (R2) has been less well studied. TGF-beta plays an essential role in Schwann cell proliferation and differentiation, and is involved in neurotrophic effects of several neurotrophic substances. TGF-beta is also expressed in benign peripheral nervous system tumors such as vestibular… CONTINUE READING

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