Expression of transduced genes in mice generated by infecting blastocysts with avian leukosis virus-based retroviral vectors.

Abstract

Transgenic mouse lines have been developed that express the tv-a receptor under the control of the chicken beta-actin promoter. These mice express the tv-a receptor in most or all tissues and in the early embryo. An avian leukosis virus (ALV)-based retroviral vector system was used for the efficient delivery of genes into preimplantation mouse embryos from… (More)

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