Expression of topoisomerase II-α in triple negative breast cancer.

  title={Expression of topoisomerase II-α in triple negative breast cancer.},
  author={Ivana Mrkli{\'c} and Zenon Pogoreli{\'c} and Vesna {\vC}apkun and Snjezana D Tomi{\'c}},
  journal={Applied immunohistochemistry & molecular morphology : AIMM},
  volume={22 3},
Triple negative breast cancer (TNBC)-defined by estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 negativity is a group with poor prognosis, due to aggressive tumor biology and lack of targeted therapy. Topoisomerase II-α (topoIIα) protein is one of the intracellular targets for anthracycline-based therapy, and high levels of topoIIα expression are recently observed in TNBC. The study included 83 patients who underwent surgery between January 2003 and… CONTINUE READING


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