Expression of toll-like receptors in the pancreas of recent-onset fulminant type 1 diabetes.

@article{Shibasaki2010ExpressionOT,
  title={Expression of toll-like receptors in the pancreas of recent-onset fulminant type 1 diabetes.},
  author={Saeko Shibasaki and Akihisa Imagawa and Sisko Tauriainen and Morio Iino and Maarit Oikarinen and Hitoshi Abiru and Keiji Tamaki and Hiroaki Seino and Katsuhiro Nishi and Izumi Takase and Yoshikatsu Okada and Sae Uno and Yuko Murase-Mishiba and Jungo Terasaki and Hideichi Makino and Iichiro Shimomura and Heikki Hy{\"o}ty and Toshiaki Hanafusa},
  journal={Endocrine journal},
  year={2010},
  volume={57 3},
  pages={211-9}
}
Fulminant type 1 diabetes, established in 2000, is defined as a novel subtype of diabetes mellitus that results from remarkably acute and almost complete destruction of pancreatic beta cells at the disease onset. In this study, we aimed to clarify the pathogenesis of fulminant type 1 diabetes with special reference to insulitis and viral infection. We examined pancreatic autopsy samples from three patients who had died soon after the onset of disease and analyzed these by immunohistochemistry… CONTINUE READING

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