Expression of toll-like receptor 4 contributes to corneal inflammation in experimental dry eye disease.

@article{Lee2012ExpressionOT,
  title={Expression of toll-like receptor 4 contributes to corneal inflammation in experimental dry eye disease.},
  author={Hyun Soo Lee and Takaaki Hattori and Eun Young Park and William Gregory Stevenson and Sunil K Chauhan and Reza Dana},
  journal={Investigative ophthalmology & visual science},
  year={2012},
  volume={53 9},
  pages={5632-40}
}
Purpose. To investigate the corneal expression of toll-like receptor (TLR) 4 and determine its contribution to the immunopathogenesis of dry eye disease (DED). Methods. Seven to 8-week-old female C57BL/6 mice were housed in a controlled environment chamber and administered scopolamine to induce experimental DED. Mice received intravenous TLR4 inhibitor (Eritoran) to block systemic TLR4-mediated activity. The expression of TLR4 by the corneal epithelium and stroma was evaluated using real-time… CONTINUE READING

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