Expression of tissue plasminogen activator in cerebral capillaries: possible fibrinolytic function of the blood-brain barrier.

@article{Zlokovic1995ExpressionOT,
  title={Expression of tissue plasminogen activator in cerebral capillaries: possible fibrinolytic function of the blood-brain barrier.},
  author={Berislav V Zlokovic and Lei Wang and Ning-ling Sun and Susan P. Haffke and Shahla Verrall and Nicholas W. Seeds and Mark J. Fisher and S. Shotkin HJ. Schreiber},
  journal={Neurosurgery},
  year={1995},
  volume={37 5},
  pages={955-61}
}
Previous work has shown that tissue plasminogen activator (tPA) is a key enzyme in the control of fibrinolysis within the vascular system. The sources of brain tPA and the mechanisms by which tPA secretion and production occur within cerebral microcirculation are not well established. In this study, expression of tPA was investigated in cerebral capillaries and capillary-depleted brain isolated from cortices of 4- to 5-week-old rats and guinea pigs. In both species, a single tPA band of M(r) 67… CONTINUE READING

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